Recorded on Sep 19, 2023 Noon – 1 pm Eastern
Real World Efficacy of Cell- and Egg-Based Quadrivalent Influenza Vaccines in Adults During the U.S. 2019-2020 Influenza Season
By Brandon Young Ph.D.
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Mutations occurring during egg-based influenza vaccine production may affect vaccine effectiveness. The mammalian cell-based quadrivalent inactivated influenza vaccine (IIV4c) demonstrated improved protection relative to egg-based vaccines in prior seasons. This study estimated the relative vaccine effectiveness (rVE) of IIV4c versus standard-dose egg-based quadrivalent inactivated influenza vaccine (IIV4e) in preventing influenza-related medical encounters (IRME) in the 2019-2020 US influenza season. This retrospective cohort study used electronic medical records linked to pharmacy and medical claims. Subjects included those aged ≥18 years vaccinated with IIV4e or IIV4c during 2019-2020 influenza season. The outcome was occurrence of IRMEs (inpatient or outpatient) defined by diagnostic codes specific to influenza (ICD-10 codes J09*–J11*). We used a doubly robust inverse probability of treatment weighting model to obtain odds ratios (OR) adjusted for age, sex, race, ethnicity, region, vaccination week, health status, frailty and baseline healthcare resource utilization. rVE was calculated by (1–OR adjusted)*100. An exploratory analysis evaluated IRME in inpatient and outpatient settings separately. The final study cohort included 1,499,215 IIV4c and 4,126,263 IIV4e recipients ≥18 years of age. Fewer IRMEs were reported in individuals with recorded IIV4c vs IIV4e. The rVE for
IIV4c vs IIIV4e for any IRME was 9.5% (95% CI 7.9 to 11.1). Inpatient and outpatient rVEs were 5.7% (2.1 to 9.2) and 11.4% (9.5 to 13.3), respectively. In age subgroup analyses, rVEs favored IIV4c except in adults ≥65 years. Adults vaccinated with IIV4c had a lower risk of IRME vs IIV4e recipients in the 2019-2020 US influenza season. These results support IIV4c as a potentially more effective than egg-based vaccines as public health measure against influenza.
Objective 1: Understand the relative vaccine effectiveness (rVE) of cell-based quadrivalent inactivated influenza vaccine (QIVc) compared with egg-based quadrivalent inactivated influenza vaccine (QIVe) in preventing cardio-respiratory hospitalizations in individuals 18–64 years of age in the U.S. 2019–20 influenza season.
Objective 2: Compare the rVE of QIVc vs. QIVe in age subgroups 18 – 49 and 50 – 64 years of age in the U.S. 2019-20 influenza season.
Objective 3: Recognize the rVE of QIVc vs. QIVe in preventing respiratory-related hospitalizations in children 4–17 years of age in the U.S. 2019-20 influenza season.
Dr. Young is the Mid-Atlantic Medical Science Liaison for CSL Seqirus. He completed his Ph.D. in Biochemistry and Molecular Biology at the Medical University of South Carolina (MUSC), with a focus on drug design against antimicrobial resistant bacteria. He then matriculated to Emory University for his Post-Doctoral research where he was a Fellowships in Research and Science Teaching Scholar. His research focused on drug and vaccine design for Ebola virus. At CSL Seqirus we have a singular global focus on influenza, we work tirelessly on cutting-edge research, transformative technologies, and the latest methods of production and distribution.
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